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This Concept Map, created with IHMC CmapTools, has information related to: Biochem A1 Tangier Disease, Apo A-1 eliminating LCAT activity, HDL synthesis leads to decreased Apo E, activity on lipoprotein lipase responsible for degredation of TAG, no ABCA1 activity leads to significantly decreased cholesterol efflux, moderate intracellular accumulation of cholesterol in tonsil cells, Apo A-1 to nascent HDL, LDL clearance lowers LDL level in plasma, heterozygous pt has decreased ABCA1 activity, normal LDL levels leads to accumulation of LDL in plasma, Apo C-II decreasing activity on lipoprotein lipase, nascent HDL leads to degradiation of Apo A-1, decrease in cholesterol efflux from peripheral tissue, activity on lipoprotein lipase responsible for degradation of TAG, HDL synthesis leads to decreased Apo C-II, tonsil cells does not manifest as clinically apparent tissue hyperplasia, decrease in cholesterol efflux leads to moderate intracellular accumulation of cholesterol, Apo A-1 to nascent HDL, Apo E decreasing maturation of VLDL, nascent HDL eliminating HDL synthesis, Apo C-II decreasing maturation of VLDL