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This Concept Map, created with IHMC CmapTools, has information related to: Gauchers, Heterozygous with N370S Variant, 4 y/o Daughter Presents with Anemia, Splenomegaly & Hepatomegaly lead to premature destruction of WBCs and RBCs, Ceredase is a modified form of and acts in place of lysosomal beta-glucocerebrosidase, Reticuloendothelial System which includes bone marrow, lysosomal beta-glucocerebrosidase deficiency of leads to decreased recycling and systemic availabilty of ceremide, urine excretion from is not possible due to insolubility of glucocerebroside, Genetic assay shows 81% reduction, Osteopenia is the cause of Bone Fractures, platelets destruction of leads to thrombocytopenia, Father are Ashkenazic Jewish, platelets destruction of leads to leukopenia, 4 y/o Daughter undergoes Genetic assay, Reticuloendothelial System which includes Spleen, glucocerebroside is normally converted to glucose, 81% reduction of WBC beta- glucosidase, Tissue-paper appearing cells known as Gaucher cells, Spleen accumulation of glycolipids results in decreased capacity to recycle RBCs, fibrils present as Tissue-paper appearing cells, Gaucher's disease is autosomal recesive