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This Concept Map, created with IHMC CmapTools, has information related to: health promotion, smoking cessation using nicoderm, immunizations for infants & children, pharmacotherapy in health promotion consider smoking cessation, pharmacotherapy in health promotion consider immunizations, menopause & hormone replacement including Conjugated Estrogens (premarin) hormone replacement therapy / prevent ovulation, increase risk of clotting, decrease risk for many cancers, increase risk for breast Ca 1.5 x Side effects: weight gain, nausea, gall bladder, mood changes Contraindications: pregnancy, breast cancer, heart disease, stroke, liver disease, migraines Drug interactions: phenytoin/phenobarbital increase metabolism, rifampicin decreasing recyling (both increase clearance) Dosing: 0.625 mg/d for replacement therapy, pharmacotherapy in health promotion consider contraception, smoking cessation using Zyban, pharmacotherapy in health promotion consider menopause & hormone replacement, immunizations for adults, contraception exemplified by Oral Contraceptives Drug interactions: Efficacy of OCP’s reduced by penicillins, tetracyclines, rifampin, ibuprofen, phenytoin, barbiturates, sulfonamides OCP’s reduce efficacy of folates, anticoagulants, insulin, hypoglycemics, methyldopa, phenothiazides, TCA’s Contraindicated: see estrogen Ethinyl estradiol mestranol is cleaved to EE by the liver / oral contraceptives 19-nor progestins (medroxyprogesterone, MPA) variable effect on ovulation / impair transport and implantation Side effects: edema, weight gain, HA, menstrual irregularities / ? avoid w/ liver disease Intrauterine device (IUD) very effective in preventing pregnancy, can be used in nulliparous women Mifepristone/RU-486 anti-progestin / given with prostaglandin to terminate pregnancy, pharmacotherapy in health promotion consider obesity & weight loss