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This Concept Map, created with IHMC CmapTools, has information related to: Myra Kinney Cmap, decreased GFR as a result of decreased glomerular blood flow leads to increase in water retention to increase blood volume to increase blood pressure to compensate and therefore increase GFR, M proteins (of which MR49 type causes AGN) which acts an antigen which will activate CD4 T Cells (TH2 dominant response), Myra Kinney presents with swelling of hands,faces, eyes, hematuria differential diagnosis pyleonephritis, classical pathway which uses classical convertase (C4 is a component of) which will split C3, Myra Kinney patient information not sexually active, causing hypertension and pitting edema and periorbital edema which could be treated with Fluid and sodium restriction, C5 convertase (C4b and C3b are components of this) split C5 into C5b, Myra Kinney patient information no dysuria, back pain, hematuria differential diagnosis Cystitis, Type III in which Antibody-antigen immune complexes form which collect at the glomerular basement membrane (due to positive charge which attracts them to the negative membrane), no dysuria, back pain makes this less likely pyleonephritis, past medical history recently had sore throat, Streptococcus pyrogenes evidence for post-streptococcal acute glomerulnephoritis, IgG antibodies against M proteins cause two types of hypersensitivity reactions Type III, Age 14 makes this less likely Renal Stone, not sexually active makes this less likely pyleonephritis, activate B cells which will lead to formation of IgG antibodies against M proteins, CD4 T Cells (TH2 dominant response) which will present antigen to activate B cells, decrease in creatinine clearance and increase in BUN, which is seen in the patient's presentation of high creatinine and BUN which increases hydrostatic pressure causing hypertension and pitting edema and periorbital edema