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Muscle activation, Hormonal stimulation G-protein cascade initiated at plasma membrane, Ca2+ moves out of SR 4 Ca2+ bind to Calmodulin, Calcium Induced Calcium Release Increased [Ca2+] opens Ca2+ channels in Sarcoplasmic Reticulum Ca2+ moves out of SR, 4 Ca2+ bind to Calmodulin Ca2+ Calmodulin activates MLCK, Ca2+ moves out of SR 4 Ca2+ bind to Troponin C, Voltage Operated Sodium Channels open when potential reaches threshold Na+ moves in, Action Potential Membrane is further depolarised Voltage Operated Calcium Channels open when potential reaches threshold, Smooth Tonic, Smooth Phasic, Voltage Operated Calcium Channels open when potential reaches threshold Ca2+ moves in