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Second Guess, gives rise to ganglionic cells of ENS which results in (?) pseudo-obstruction of bowel, alterations in Rho subfamily leading to alterations in cytoskeleton, bloody diarrhea possibly due to? overgrowth of C. Diff, hirschsprungs charac by incomplete migration of neural crest cells, a loss of cell shape and tight junction integrity this leads to cell lysis, blood in the lumen, and disruption of the epithelium, incomplete migration of neural crest cells which gives rise to ganglionic cells of ENS, encodes for protein which assists cells of neural crest in movement proteins include glial derived neotropic factor and endothelin 3, pseudo-obstruction of bowel leading to?? bloody diarrhea, interactions of two mutated gens specifically RET, interactions of two mutated gens specifically ENRB