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This Concept Map, created with IHMC CmapTools, has information related to: Osteoporosis CBL A1, estrogen inhibits IL-6, Betty VanCleef had a family hx, Betty VanCleef had a recent fall, transcription factor increasing intestinal absorption, Z score compares pt to age-matched population, acidic environment in bone promotes demineralization of bone, 25-OH D3 to 1,25diOH D3, Lifestyle Factors which are risk factors for Osteoporosis, Betty VanCleef admits high diet soda intake, transcription factor stimulates production of osteoprotegerin, inital evaluation including physical exam, demineralization of bone releases Calcium, Betty VanCleef admits poor nurtition, skeletal fragility increase risk of compression fx, deficiency of estrogen, family hx of hip fx, estrogen desensitizes bone, prostaglandin synthase (cyclooxygenase) produces COX-II enzymes, osteoblasts increases production of 1,25diOH D3, carbonic anhydrase 2 produces carbonic acid