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MDD FINAL, anxiety-type behavior in adult mice, ACTH responses to CRF stimulation are increased ESL + MDD, Early Life Stress (ELS) Nemeroff 2004 studied in Animal Models, Antidepressants (1) are Treatments (SEE ABOVE), CNS primary function is to facilitate Information Processing, Paraventricular Nucleus (PVN) to secrete Corticotrophin -Releasing Factor (CRF), Protracted time course for positive results despite speedy metabolism effects, EARLY antidepressant Treatment (animals) LEADS TO Increased production, STRESS causes Paraventricular Nucleus (PVN), concentrations of neuropeptides on intracellular signaling