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AZ genetics - DKS, alteration causing increased deposition by APP of plaques, Presenilin 1 gene (PSEN1); protein (PS1) known mutations over 90 known, Presenilin 2 gene (PSEN2); protein (PS2) location Chromosome 1, autosomal dominance in polymorphisms of genes occurring within Amyloid Precursor Protein (APP) gene, Presenilin 1 gene (PSEN1); protein (PS1) known mutations found in, Familial Alzheimer Disease (FAD) occurs in 5-10% of all AD cases, include Asn141Ile found repeatedly in Volga Germans, Chromosome 1 overlaps with early onset AD, Apolipoprotein E gene (APOE) in APOE type 4 high allele copy, Amyloid Precursor Protein (APP) gene leads to (Tomita, 1997) alteration causing