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AZ neuropathology - JDN Rev, focus of treatment includes clearing, AMYLOID HYPOTHESIS: debate as to which is the initiating event TAU HYPOTHESIS, treatment to look at Mild cognitive impairment, focus of treatment includes prevention - preemptive, clinical testing including psychometric tests, plaques therefore focus of treatment, Mild cognitive impairment with APO-e4, prevention - preemptive formation of a-beta 1-40, Mild cognitive impairment diagnosed by clinical testing, Neuropathology of AZ begins at least a decade before!!!!! dementia