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BD Final, prevalence is about 1-1.5%, Age of onset is variable, Genetic methodologies include familial studies, BD I characterized by Depressive Episode, Linkage has been a blunt instrument, Cyclothymia characterized by chronic fluctuations, recurrent averages 4 epsiodes in 10 years, debate only diagnosed following 1 or more manic episode, 1 or more manic episode at least 1 week of (or hospitalization for) Elevated/euphoric mood, Concordance Rates determined from Family Studies