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MDD serotonin - JDN-Rev, BDNF is a Gene, CREB protein blinds to cAMP, CREB protein regulates Gene, chronic administration of SSRI increases expression of CREB protein, serotonin linked to suicide, receptot-coupled signal transduction pathways including cAMP, long allele is protective no increase in baseline (2 copies), serotonin interacts with Serotonin transporter, 80% chance of dep across lifetime (s2 copies) see Stress and cortisol, short following 80% chance of dep across lifetime (s2 copies)