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This Concept Map, created with IHMC CmapTools, has information related to: LDL receptor deficiency 010912II, 10 year old girl with significant Family History, LDL When encounter receptor cause invagination into Clathrin Coated Pits, Cholesterol synthesis intracellularly controlled by HMG-CoA Reductase, Transcription Factor increases transcription of HMG-CoA Reductase, 10 year old girl presents with Xanthomas, 7-α Hydroxylase into Cholic Acid, Amino acids, fatty acids, phospholipids Make up remnants of LDL, nucleus and bind to SRE, Oxidized LDL occurs because of Oxidants in the blood (NO, H2O2, etc), Atherosclerotic plaque formation made up of Cholesterol, 10 year old girl presents with Normal Triglyceride Levels, Cholesterol in liver broken down into 7-α Hydroxylase, SRE acts as Transcription Factor, nascent VLDL acquires Apo E, Xanthomas Leads to Genetic Testing, Cholesterol heightened levels in pt.secondary to lack of Apo B/E Receptors (LDL receptors), Glycine/Taurine to make bile salts, 1150 mg/dl (when measured at 3 yrs old) Leads to Genetic Testing, Apo B/E Receptors (LDL receptors) recognize ApoB100, ACAT to Cholesterol Esters