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This Concept Map, created with IHMC CmapTools, has information related to: Hyperhomocysteinemia I, homocysteine can undergo transsulfuration, homocysteine when methylated via methionine synthase (MS), Methionine synthase reductase (MTRR) to form methyl cobalamin, homocysteine when found in high concentration in the blood called hyperhomocysteinemia, S-adenosylhomocysteine (SAH) via SAH hydrolase is converted to homocysteine, Methionine via methionine adenosyltransferase is converted to S-adenosylmethionine (SAM), cystathionine beta-synthase ???? transsulfuration, hyperhomocysteinemia can result in endothelial damage, 5-methyltetrahydrofolate (5-MTHF) is the methyl donor for methionine synthase (MS), Pyridoxal phosphate (vit B6) is a co-factor for cystathionine beta-synthase, cystathionine beta-synthase forms cystathionine, 5-methyltetrahydrofolate (5-MTHF) methyl group is transferred to cobalamin (I), cobalamin (I) generating methyl cobalamin, endothelial damage possibly results in inactivation of NO, methionine synthase (MS) is dependent on cobalamin, hyperhomocysteinemia treated with Folic acid, homocysteine can undergo remethylation, remethylation via methionine synthase (MS), Folic acid helps maintain Folate cycle, 5,10-methylenetetrahydrofolate via MTHFR