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This Concept Map, created with IHMC CmapTools, has information related to: Week 6 Group A4 - Rita Arthur, Rita Arthur presents with bilateral hand & wrist pain, HLA class II molecule binds peptide of self antigen, IFN-alpha activates macrophage, CD4 T-Cells matures to TH2 Cell, neutrophils activate macrophage, prostaglandins causes peripheral sensitization, disease associated HLA allotype encodes HLA class II molecule, arachidonic acid aggregates in synovial fluid, silent nociceptors leads to hyperalgesia, synovial fluid in synovial joints, HLA class II molecule binds T-Cell receptor, IFN-alpha activates synovial fibroblasts, CD4 T-Cells matures to TH1 Cell, synovial fibroblasts part of synovium, IL-6 causes inflammation, IL-6 causes fever, macrophage releases IL-6, peripheral sensitization recruits silent nociceptors, synovial fibroblasts releases IL-1, B lymphocytes producing rheumatoid factor (auto-Ab)