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This Concept Map, created with IHMC CmapTools, has information related to: Week 8 Group A4 - Nancy Cooper, PICO Question: How does a patient's advanced maternal age affect risk of trisomy 21 within the fetus compared to pregnancies of women younger than 35? addressed using UpToDate article entitled: Overview of Prenatal Screening and Diagnosis of Down Syndrome literature review current through August 2012, pre-natal diagnosis counseling regarding risks for Nancy Cooper, meiotic non-disjunction caused by oocytes arrested in Prophase I throughout life until ovulation late in life, St. John's Wort may be contraindicated in pregnancy, PICO Question: How does a mother's smoking and use of alcohol affect fetal development as compared to a mother who does not smoke or drink during pregnancy? addressed using Micromedics article entitled: Ethanol: Under adverse affects category, potentially harmful diet habits & supplementation allows generation of PICO Question: How does poor diet and supplementation in pregnant women affect fetal development compared to pregnant women following proper diet and supplementation?, UpToDate article entitled: Overview of Prenatal Screening and Diagnosis of Down Syndrome literature review current through August 2012 validates Trisomy 21, Nancy Cooper presents with advanced maternal age (37), potentially harmful exogenous substances use including smoking, Smoking cessation disussion for Nancy Cooper, folate deficiency reduces nucleotide synthesis, recommendaion to discontinue intake of St. John's Wort for Nancy Cooper, Micromedics article entitled: Ethanol: Under adverse affects category results in recommendation to stop alcohol intake and supplement with folate, UpToDate article entitled: Nutrition and Pregnancy Review current through August 2012 validates low birth weight, oocytes arrested in Prophase I throughout life until ovulation late in life increasing risk of Trisomy 21, UpToDate article entitled: Smoking and Pregnancy Review current through August 2012 resuts in Smoking cessation disussion, UpToDate article entitled: Smoking and Pregnancy Review current through August 2012 validates fetal oxygen delivery, potentially harmful diet habits & supplementation including St. John's Wort, smoking decreases fetal oxygen delivery, PICO Question: How does poor diet and supplementation in pregnant women affect fetal development compared to pregnant women following proper diet and supplementation? addressed using UpToDate article entitled: Nutrition and Pregnancy Review current through August 2012