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This Concept Map, created with IHMC CmapTools, has information related to: Week 9 Group A4 - Mark Davis, necrosis and apoptosis leads to proximal muscle atrophy, Mark Davis has family history, necrosis and apoptosis causes inflammation, F actin to basal laminae of muscle, Xp 21 Locus leads to loss of dystrophin, DMD gene at Xp 21 Locus, single base pair mutation following x linked inheritance pattern, Ca++ permeability increases Ca++ signalling, replacement of injured tissue with adipose and connective tissue presents as muscle weakness, family history of maternal uncle passing from unknown causes, Mark Davis presents with Gower's sign, creatine kinase sign of cardiomyopathy, single base pair mutation in DMD gene, replacement of injured tissue with adipose and connective tissue presents as pseudo hypertrophy, x linked inheritance pattern inherited from mother with developmental delays, dystrophin anchors F actin, dystrophin part of dystrophin glycoprotein complex in sarcolemma, basal laminae of muscle through protein-protein interactions, dystrophin leads to sarcolemma degradation, inflammation lead to replacement of injured tissue with adipose and connective tissue