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This Concept Map, created with IHMC CmapTools, has information related to: dna replication, an RNA primer which is replaced by DNA polymerase I, synthesized continuously by DNA polymerase, DNA polymerase I then the Okazaki fragments are linked covalently, enzymes and proteins such as DNA ligase, the Okazaki fragments are linked covalently by DNA ligase, semiconservative meaning one strand is conserved, enzymes and proteins such as gyrase, discontinuously synthesized first RNA primase, DNA helicase unzips DNA helix, enzymes and proteins such as DNA helicase, gyrase produce breaks in DNA to prevent knotting and strain, DNA helix forming replication fork, enzymes and proteins such as DNA polymerase I, DNA Replication is semiconservative, free nucleotides in 5' -> 3' direction, enzymes and proteins such as RNA primase, replication fork forms leading strand, enzymes and proteins such as DNA polymerase III, lagging strand is discontinuously synthesized, single stranded binding proteins keep DNA separated